Dependence of electrical activity and calcium influx-controlled prolactin release on adenylyl cyclase signaling pathway in pituitary lactotrophs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F06%3A00042268" target="_blank" >RIV/67985823:_____/06:00042268 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Dependence of electrical activity and calcium influx-controlled prolactin release on adenylyl cyclase signaling pathway in pituitary lactotrophs
Original language description
Pituitary lactotrophs in vitro fire extracellular Ca2+ -dependent action potentials spontaneously through still unidentified pacemaking channels and the associated voltage-gated Ca2+ influx is sufficient to maintain basal prolactin secretion high and steady. Elevation in cAMP and cGMP levels in lactotrophs is also accompanied with increased electrical activity and prolactin release, cAMP facilitates these effects predominantly in a protein kinase A- and Epac cAMP receptor-independent manner
Czech name
Závislost elektrickou aktivitou a vstupem vápníku kontrolované sekrece prolaktinu na adenylyl cyklázové signalizační dráze v hypofyzárních laktotropech
Czech description
Hypofyzární laktotropní buňky in vitro mají spontánní vápníkové akční potenciály, a tato jejich elektrická aktivita je zodpovědná za vstup Ca2 do buňky a vysokou klidovou sekreci prolaktinu. Zvýšení klidové hladiny cAMP a cGMP také vede ke zvýšení elektrické aktivity a sekrece. Účinek cAMP v laktotropech není závislý na protein kinase-A ani na Epac cAMP receptoru
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LC554" target="_blank" >LC554: Neuroscience Centre</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Endocrinology
ISSN
0888-8809
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
2231-2246
UT code for WoS article
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EID of the result in the Scopus database
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