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Dependence of electrical activity and calcium influx-controlled prolactin release on adenylyl cyclase signaling pathway in pituitary lactotrophs

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F06%3A00042268" target="_blank" >RIV/67985823:_____/06:00042268 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Dependence of electrical activity and calcium influx-controlled prolactin release on adenylyl cyclase signaling pathway in pituitary lactotrophs

  • Original language description

    Pituitary lactotrophs in vitro fire extracellular Ca2+ -dependent action potentials spontaneously through still unidentified pacemaking channels and the associated voltage-gated Ca2+ influx is sufficient to maintain basal prolactin secretion high and steady. Elevation in cAMP and cGMP levels in lactotrophs is also accompanied with increased electrical activity and prolactin release, cAMP facilitates these effects predominantly in a protein kinase A- and Epac cAMP receptor-independent manner

  • Czech name

    Závislost elektrickou aktivitou a vstupem vápníku kontrolované sekrece prolaktinu na adenylyl cyklázové signalizační dráze v hypofyzárních laktotropech

  • Czech description

    Hypofyzární laktotropní buňky in vitro mají spontánní vápníkové akční potenciály, a tato jejich elektrická aktivita je zodpovědná za vstup Ca2 do buňky a vysokou klidovou sekreci prolaktinu. Zvýšení klidové hladiny cAMP a cGMP také vede ke zvýšení elektrické aktivity a sekrece. Účinek cAMP v laktotropech není závislý na protein kinase-A ani na Epac cAMP receptoru

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/LC554" target="_blank" >LC554: Neuroscience Centre</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2006

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular Endocrinology

  • ISSN

    0888-8809

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    16

  • Pages from-to

    2231-2246

  • UT code for WoS article

  • EID of the result in the Scopus database