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Effects of pertussis toxin on vascular reactivity of femoral arteries in WKY and SHR

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F07%3A00088965" target="_blank" >RIV/67985823:_____/07:00088965 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effects of pertussis toxin on vascular reactivity of femoral arteries in WKY and SHR

  • Original language description

    Elevated blod pressure (BP) of hypertensive rats can be reduced either by the inhibition of calcium influx with nifedipine or by the inactivation of inhibitory G proteins with pertussis toxin (PTX).In our study BP reduction after PTX injection was accompanied by impaired norepinephrine-induced contraction only in femoral arteries from WKY. On the contrary, nifedipine inhibited norepinephrine-induced contractions not only in control WKY and SHR but also in PTX-treated SHR

  • Czech name

    Vliv pertussis toxinu na vaskulární reaktivitu femorálních arterií u WKY a SHR

  • Czech description

    Zvýšený krevní tlak (TK) u hypertensních potkanů může být snížen buď inhibicí influxu vápníku nifedipinem nebo inaktivací inhibičních G proteinů pertussis toxinem (PTX). V naší studii bylo snížení TK po injekci PTX provázeno oslabením kontrakcí vyvolaných noradrenalinem pouze u femorálních arterií z WKY. Naopak, nifedipin inhiboval kontrakce vyvolané noradrenalinem nejen u kontrolních WKY, ale také u SHR premedikovaných PTX

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/1M0510" target="_blank" >1M0510: Centre for cardiovascular research</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Nitric oxide signaling pathways

  • ISBN

    978-80-8071-094-1

  • Number of pages of the result

    6

  • Pages from-to

    89-94

  • Number of pages of the book

  • Publisher name

    Advent-Orion

  • Place of publication

    Bratislava

  • UT code for WoS chapter