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Functional dynamic compartmentalization of respiratory chain intermediate substrates: Implications for the control of energy production and mitochondrial diseases

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F08%3A00314556" target="_blank" >RIV/67985823:_____/08:00314556 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Functional dynamic compartmentalization of respiratory chain intermediate substrates: Implications for the control of energy production and mitochondrial diseases

  • Original language description

    The role of cytochrome c and coenzyme Q was analyzed in the attenuation of the Complex II and Complex IV at pharmacological inhibition of respiratory flux. It allowed calculations of an exact stoichiometry between the respiratory chain complexes and thecofactors, cytochrome c and coenzyme Q, for skeletal muscle and liver. By these exact quantifications they revealed a reserve that can be recruited to maintain energy production when certain respiratory chain components are inhibited. The size of the reserve was again found to be different for the skeletal muscle and the liver

  • Czech name

    Funkční dynamická kompartmentalizace intermediátů respiračního řetězce: důsledky pro řízení produkce energie a mitochondriální nemoce

  • Czech description

    Úloha cytochromu c a koenzymu Q při atenuovaných komplexech II a IV byla kvantifikována určením stechiometrie komplexů vs. kofaktorů u mitochondrií kosterního svalu a jater. Bylo zjištěno, že energie se rekrutuje až po dosažení jistého thresholdu neúčinosti komplexů

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Biochemistry and Cell Biology

  • ISSN

    1357-2725

  • e-ISSN

  • Volume of the periodical

    40

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

  • UT code for WoS article

    256536900016

  • EID of the result in the Scopus database