Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F10%3A00345610" target="_blank" >RIV/67985823:_____/10:00345610 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats

Original language description

The aim of the study was to elucidate whether, when and where the transcripts of the clock genes Per1 and Per2 and the immediate early gene c-fos are spontaneously expressed and/or induced by light in the newborn retina. Endogenous expression of Per1 wasdetected in the neuroblastic retina, and Per2 expression was detected in the inner part of the neuroblastic retina from birth. Light pulses induced c-fos expression in ganglion cells from postnatal day 1 (P1). Light pulses also induced the expression ofPer1 and c-fos in the retinal pigment epithelium until P3, but not afterward. Expression of Per2 was not photoresponsive until P10. The data demonstrate that the rat retina is photosensitive immediately after birth. During early postnatal development, the spatial distribution of spontaneous and light-induced gene expression within the retinal layers changes gradually

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Comparative Neurology

ISSN

0021-9967

e-ISSN

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Volume of the periodical

518

Issue of the periodical within the volume

17

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

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UT code for WoS article

280311700013

EID of the result in the Scopus database

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