Tumor necrosis factor ? sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F10%3A00347210" target="_blank" >RIV/67985823:_____/10:00347210 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Tumor necrosis factor ? sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine
Original language description
In our experiments the possible influence of TNFa on presynaptic spinal cord TRPV1 receptor function was investigated. Our results indicate that TNFa may have a significant impact on nociceptive signaling at the spinal cord level that could be mediated by increased responsiveness of presynaptic TRPV1 receptors to endogenous agonists. This could be of major importance, especially during pathological conditions, when increased levels of TNFa and TNFR are present in the spinal cord
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroinflammation
ISSN
1742-2094
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
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Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
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UT code for WoS article
282385800001
EID of the result in the Scopus database
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