Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F11%3A00366420" target="_blank" >RIV/67985823:_____/11:00366420 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.neuroscience.2011.09.028" target="_blank" >http://dx.doi.org/10.1016/j.neuroscience.2011.09.028</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neuroscience.2011.09.028" target="_blank" >10.1016/j.neuroscience.2011.09.028</a>

Result language
angličtina
Original language name
Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light
Original language description
The aim of the study was to elucidate whether feeding regime may affect the molecular mechanisms generating rhythmicity in the suprachiasmatic nucleus (SCN) under conditions in which the rhythmicity is disturbed, as occurs under constant light. Due to exposure to constant light, the rats fed ad libitum became arrhythmic, while those exposed to restricted feeding were active mostly during the time of food availability. Restricted feeding induced significant circadian rhythms in Rev-erb? and Bmal1 gene expression in the SCN. These finding demonstrate that, under specific conditions, when the rhythmicity of the SCN is disturbed and other temporal entraining cues are lacking, the SCN molecular clockwork may likely sense temporal signals from changes in metabolic state delivered by normocaloric food
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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