Early rhythmicity in the fetal suprachiasmatic nuclei in response to maternal signals detected by omics approach
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F22%3A00557889" target="_blank" >RIV/67985823:_____/22:00557889 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1371/journal.pbio.3001637" target="_blank" >https://doi.org/10.1371/journal.pbio.3001637</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pbio.3001637" target="_blank" >10.1371/journal.pbio.3001637</a>
Alternative languages
Result language
angličtina
Original language name
Early rhythmicity in the fetal suprachiasmatic nuclei in response to maternal signals detected by omics approach
Original language description
The suprachiasmatic nuclei (SCN) of the hypothalamus harbor the central clock of the circadian system, which gradually matures during the perinatal period. In this study, time-resolved transcriptomic and proteomic approaches were used to describe fetal SCN tissue-level rhythms before rhythms in clock gene expression develop. Pregnant rats were maintained in constant darkness and had intact SCN, or their SCN were lesioned and behavioral rhythm was imposed by temporal restriction of food availability. Model-selecting tools dryR and CompareRhythms identified sets of genes in the fetal SCN that were rhythmic in the absence of the fetal canonical clock. Subsets of rhythmically expressed genes were assigned to groups of fetuses from mothers with either intact or lesioned SCN, or both groups. Enrichment analysis for GO terms and signaling pathways revealed that neurodevelopment and cell-to-cell signaling were significantly enriched within the subsets of genes that were rhythmic in response to distinct maternal signals. The findings discovered a previously unexpected breadth of rhythmicity in the fetal SCN at a developmental stage when the canonical clock has not yet developed at the tissue level and thus likely represents responses to rhythmic maternal signals.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/GA19-01845S" target="_blank" >GA19-01845S: Identification of rhythmic maternal signals using circadian transcriptome and proteome analyses of the fetal suprachiasmatic nuclei</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLOS Biology
ISSN
1544-9173
e-ISSN
1545-7885
Volume of the periodical
20
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
22
Pages from-to
e3001637
UT code for WoS article
000880645300001
EID of the result in the Scopus database
2-s2.0-85131018959