In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00434397" target="_blank" >RIV/67985823:_____/14:00434397 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0107360" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0107360</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0107360" target="_blank" >10.1371/journal.pone.0107360</a>

Result language
angličtina
Original language name
In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei
Original language description
Results of the study demonstrate that the circadian clock in the fetal rat suprachiasmatic nuclei develops gradually. At embryonic day 19 (E19), i.e., 4 days before delivery, the rhythms in expression of canonical clock genes Per2 and Bmal1 were absent and the clock developed just before birth. Expression of the clock gene Nr1d1 was rhythmic at E19 in absence of other clock gene expression rhythms and was thus likely driven by maternal cues instead of the core clockwork. The result suggest a molecular mechanism of how the rhythmic maternal cues entrain the developing fetal clock in the suprachiasmatic nuclei in vivo
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/GAP303%2F12%2F1108" target="_blank" >GAP303/12/1108: Development of circadian timekeeping system during ontogenesis under conditions of functional and/or disturbed maternal circadian system</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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