Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F12%3A00381980" target="_blank" >RIV/67985823:_____/12:00381980 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/emboj.2012.207" target="_blank" >http://dx.doi.org/10.1038/emboj.2012.207</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/emboj.2012.207" target="_blank" >10.1038/emboj.2012.207</a>

Result language
angličtina
Original language name
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling
Original language description
Results provide the first insights into the molecular mechanisms underlying cold allodynia induced by P-CTX-1, the most potent ciguatoxin present in the Pacific Ocean. The results demonstrate that: a) ciguatoxin induced cold allodynia can be reproduced in a mouse model: following injection of minute quantities of P-CTX-1 into the sole of the paw, these mice exhibited clear signs of pain at moderately cool ambient temperatures, which were alleviated by warming. b) P-CTX-1 acts by sensitizing a specific subset of sensory neurons, characterized by the expression of the cation channel TRPA1 and c) pharmacological inhibition or genetic disruption of TRPA1 in mice strongly reduce the severity of cold allodynia upon P-CTX-1 injection
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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