Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00391719" target="_blank" >RIV/67985823:_____/13:00391719 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijdevneu.2012.11.011" target="_blank" >http://dx.doi.org/10.1016/j.ijdevneu.2012.11.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijdevneu.2012.11.011" target="_blank" >10.1016/j.ijdevneu.2012.11.011</a>
Alternative languages
Result language
angličtina
Original language name
Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2)
Original language description
In control animals activities of individual antioxidant enzymes revealed different changes during the studied postnatal period (PD12-PD47).In animals in which seizures were induced by DL-homocysteic acid, the activity of total SOD, SOD1 and particularlySOD2 significantly increased at 20 h and 6 days of survival following the seizures.Upregulation of SOD2 was also confirmed in mitochondria at the protein level by immunoblotting.The activities of other antioxidant enzymes did not differ from the appropriate controls. The findings suggest that antioxidant defense in brain of immature animals during seizures is limited and may thus contribute to the occurrence of oxidative stress
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Developmental Neuroscience
ISSN
0736-5748
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
123-130
UT code for WoS article
000314557500005
EID of the result in the Scopus database
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