Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00398866" target="_blank" >RIV/67985823:_____/13:00398866 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1523/JNEUROSCI.1473-13.2013" target="_blank" >http://dx.doi.org/10.1523/JNEUROSCI.1473-13.2013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1523/JNEUROSCI.1473-13.2013" target="_blank" >10.1523/JNEUROSCI.1473-13.2013</a>

Result language
angličtina
Original language name
Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition
Original language description
This study presents novel insights into cutaneous cold transduction mechanisms by investigating the molecular mechanism of how camphor modulates cold transduction to induce sensitization to cooling. We used extracellular and patch clamp electrophysiological techniques in combination with transgenic mice, calcium imaging and a high throughput FLIPRTETRA-based screening assay and present first evidence of an involvement of KV7.2/3 channels, which form the neuronal M-current, in the modulation of TRPM8-dependent cold transduction in cutaneous cold nociceptors
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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