Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00420861" target="_blank" >RIV/67985823:_____/13:00420861 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jhet.1742" target="_blank" >http://dx.doi.org/10.1002/jhet.1742</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jhet.1742" target="_blank" >10.1002/jhet.1742</a>

Result language
angličtina
Original language name
Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications
Original language description
Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonists of muscarinic receptors. One of the compounds was found tobe 3 to 8 times more potent at M2 than other subtypes of muscarinic receptors in competition binding and selective for the M1 receptors over M3 and M5 in antagonizing accumulation of inositol phosphates induced by muscarinic agonist carbachol
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
<a href="/en/project/GA305%2F09%2F0681" target="_blank" >GA305/09/0681: Molecular mechanisms of functional selectivity of atypical agonists at muscarinic receptors</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)