Radioligand Binding at Muscarinic Receptors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00458560" target="_blank" >RIV/67985823:_____/16:00458560 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_3" target="_blank" >http://dx.doi.org/10.1007/978-1-4939-2858-3_3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_3" target="_blank" >10.1007/978-1-4939-2858-3_3</a>

Result language
angličtina
Original language name
Radioligand Binding at Muscarinic Receptors
Original language description
Five subtypes of muscarinic acetylcholine receptors denoted M1 through M5 have been cloned. Muscarinic receptors mediate a wide array of physiological functions and impairment of muscarinic signaling is involved in numerous pathological conditions including Alzheimer’s disease and schizophrenia. Reliable radioligand binding techniques allow study of involvement of individual muscarinic receptor subtypes in the physiology and pathology of muscarinic signaling, and study of the structure of muscarinic receptors and structure-activation relationship of muscarinic ligands. Here we discuss the current state of knowledge of radioligand binding experiments at muscarinic receptors from the perspective of available radioligands and selective unlabeled muscarinic ligands.
Czech name
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Czech description
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Project
<a href="/en/project/GBP304%2F12%2FG069" target="_blank" >GBP304/12/G069: Project of excellence in the field of neuroscience</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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