Utilization of Superfused Cerebral Slices in Probing Muscarinic Receptor Autoregulation of Acetylcholine Release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00458556" target="_blank" >RIV/67985823:_____/16:00458556 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_12" target="_blank" >http://dx.doi.org/10.1007/978-1-4939-2858-3_12</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_12" target="_blank" >10.1007/978-1-4939-2858-3_12</a>
Alternative languages
Result language
angličtina
Original language name
Utilization of Superfused Cerebral Slices in Probing Muscarinic Receptor Autoregulation of Acetylcholine Release
Original language description
Signal transmission from cholinergic nerves is mediated by two receptor families: ionotropic nicotinic and metabotropic (G-protein coupled) muscarinic receptors. The muscarinic receptor family comprises five receptor subtypes (M1 through M5), each encoded by its own gene. Individual subtypes play important specific roles in many physiological processes, ranging from vegetative to cognitive functions and memory. Cloning of individual muscarinic receptor subtypes has enabled targeted studies of ligand binding and activation characteristics of the recombinant protein and a rapid increase in the development of receptor selective drugs for various potential therapeutic uses. Results of testing new drugs obtained on recombinant proteins need to be verified using systems that better mimic a physiological environment. Here we provide a brief outline and examples of the utilization of superfused brain slices for probing drug effects on muscarinic autoreceptor-mediated regulation of acetylcholine release.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Muscarinic Receptor: From Structure to Animal Models
ISBN
978-1-4939-2857-6
Number of pages of the result
13
Pages from-to
221-233
Number of pages of the book
287
Publisher name
Springer
Place of publication
New York
UT code for WoS chapter
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