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Plasma Membrane Density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00420970" target="_blank" >RIV/67985823:_____/13:00420970 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Plasma Membrane Density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex

  • Original language description

    GABAB-R1a, GABAB-R1b, GABAB-R2, Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta subunit protein content was determined by quantitative immunoblotting in PM isolated from brain cortex of rats of different ages: between postnatal day1 (PD1) and 90 (PD90). PM density of GABAB-R1alpha, GABAB-R2, Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta was high at birth. The intensity of GABAB-R1a and GABAB-R2 subunits signal decreased between the birth and PD15: to 55 % (R1a, **) and 51 % (R2, **), respectively. Contrarily, PM level of the cognate G-proteins Gi1/Gi2alpha, Gi3alpha, Goalpha, Gzalpha and Gbeta was unchanged in the course of the whole postnatal period of brain cortex development. Maturation of GABAB-R cascade was substantially different from ontogenetic profile of Na, K-ATPase, which was low at birth and increased between the birth and PD25. In adult rats, membrane content of Na, K-ATPase was 3-times higher than around the birth

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

  • Volume of the periodical

    62

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    13

  • Pages from-to

    547-559

  • UT code for WoS article

    000327444700009

  • EID of the result in the Scopus database