Cytochrome c Is Tyrosine 97 Phosphorylated by Neuroprotective Insulin Treatment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F13%3A00424725" target="_blank" >RIV/67985823:_____/13:00424725 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0078627" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0078627</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0078627" target="_blank" >10.1371/journal.pone.0078627</a>

Result language
angličtina
Original language name
Cytochrome c Is Tyrosine 97 Phosphorylated by Neuroprotective Insulin Treatment
Original language description
We investigated the phosphorylation status of Cytc in ischemic brain and sought to determine if insulin-induced neuroprotection and inhibition of Cytc release was associated with phosphorylation of Cytc. Ischemic brains demonstrated no detectable tyrosine phosphorylation. In contrast Cytc isolated from brains treated with insulin showed robust phosphorylation of Cytc, and the phosphorylation site was unambiguously identified as Tyr97 . These data suggest a mechanism whereby Cytc is targeted for phosphorylation by insulin signaling, which may prevent its release from the mitochondria and the induction of apoptosis
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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