Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00429211" target="_blank" >RIV/67985823:_____/14:00429211 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1042/CS20130479" target="_blank" >http://dx.doi.org/10.1042/CS20130479</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1042/CS20130479" target="_blank" >10.1042/CS20130479</a>

Result language
angličtina
Original language name
Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition
Original language description
In the present study, multiple structural EET analogues were synthesized based on the EET pharmacophore and vasodilator structure-activity studies. Two EET analogues in which the COOH group at carbon 1 of the EET pharmacophore was replaced with either anaspartic acid (EET-A) or a heterocyclic surrogate (EET-X) lowered blood pressure in spontaneously hypertensive rats and in angiotensin II (AngII) hypertension. Additional experiments demonstrated that EET-A inhibits epithelial sodium channel (ENaC) activity in cultured cortical collecting duct cells and reduced renal expression of ENaC subunits in AngII hypertension. In conclusion, we have characterized EET-A as an orally active antihypertensive EET analogue that protects vascular endothelial functionand has ENaC inhibitory activity in AngII hypertension
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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