Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00431289" target="_blank" >RIV/67985823:_____/14:00431289 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.biocel.2014.06.010" target="_blank" >http://dx.doi.org/10.1016/j.biocel.2014.06.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biocel.2014.06.010" target="_blank" >10.1016/j.biocel.2014.06.010</a>
Alternative languages
Result language
angličtina
Original language name
Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate
Original language description
Tocopheryl succinate (TOS), a redox-silent analogue of vitamin E, suppresses cell growth in a number of clinical and experimental cancers, inhibits mitochondrial dehydrogenase (SDH) and activates reactive oxygen species (ROS) generation. The aim of thisstudy was to test whether TOS also inhibits glycerol-3-phosphate dehydrogenase (mGPDH), another flavoprotein-dependent enzyme of the mitochondrial respiratory chain because there are differences between electron transfer pathway from SDH and mGPDH to coenzyme Q pool. We found that TOS-induced inhibition of mGPDH is more pronounced than TOS-induced inhibition of SDH and that the inhibitory effect of TOS for both substrates is exerted at different location of the particular dehydrogenase. Our data indicate that the inhibition of mGPDH activity could also play a role in TOS-induced growth suppression in neoplastic cells
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP304%2F12%2F0259" target="_blank" >GAP304/12/0259: Mutual interactions of various vasoactive systems, reactive oxygen species and G proteins in experimental hypertension</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Biochemistry and Cell Biology
ISSN
1357-2725
e-ISSN
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Volume of the periodical
53
Issue of the periodical within the volume
AUG
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
409-413
UT code for WoS article
000340340400047
EID of the result in the Scopus database
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