ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00428164" target="_blank" >RIV/67985823:_____/14:00428164 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbabio.2013.08.007" target="_blank" >http://dx.doi.org/10.1016/j.bbabio.2013.08.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbabio.2013.08.007" target="_blank" >10.1016/j.bbabio.2013.08.007</a>

Result language
angličtina
Original language name
ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase
Original language description
Mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) and succinate dehydrogenase (SDH) are important source of reactive oxygen species (ROS), but the mechanism of their production is still poorly understood. In this study we demonstrate two distinctmechanisms, with flavin being the most likely source of electron leak in SDH and coenzyme Q site in mGPDH. Furthermore, mGPDH was found to associate into homooligomers and supercomplexes capable to produce ROS similarly as the isolated enzyme itself
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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