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High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F09%3A00338638" target="_blank" >RIV/67985823:_____/09:00338638 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria

  • Original language description

    A high rates of mGPDH-dependent ROS production were observed in liver, heart and brain mitochondria treated with antimycin. When related to activity of mGPDH, 3-39-fold higher ROS production was found in contrast to succinate dehydrogenase- or NADH dehydrogenase-dependent ROS production. It was also 22-66 higher compared to that in BAT. Our results demonstrate high efficiency of mGPDH-dependent ROS production localized to the dehydrogenase + CoQ and complex III, in mammalian mitochondria with a low content of mGPDH and suggest its endogenous inhibition in BAT

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2009

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Archives of Biochemistry and Biophysics

  • ISSN

    0003-9861

  • e-ISSN

  • Volume of the periodical

    481

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

  • UT code for WoS article

    262540500004

  • EID of the result in the Scopus database