Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00431306" target="_blank" >RIV/67985823:_____/14:00431306 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/ijo.2013.230" target="_blank" >http://dx.doi.org/10.1038/ijo.2013.230</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ijo.2013.230" target="_blank" >10.1038/ijo.2013.230</a>

Result language
angličtina
Original language name
Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice
Original language description
In this study, the effects of natural bile acid, chenodeoxycholic acid (CDCA), on dietary obesity, UCP1 in both interscapular BAT and in white adipose tissue (brite cells in WAT), were characterized in dietary-obese mice. In the 8-week reversion, the CDCA intervention resulted in a dose-dependent reduction of obesity, dyslipidaemia and glucose intolerance, which could be largely explained by a transient decrease in food intake. The 3-week reversion revealed mild CDCA-dependent and food intake-independent induction of UCP1-mediated thermogenesis in interscapular BAT, negligible increase of UCP1 in subcutaneous WAT and a shift from carbohydrate to lipid oxidation
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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