Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10290561" target="_blank" >RIV/00216208:11110/14:10290561 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/14:00427934 RIV/00064165:_____/14:10290561
Result on the web
<a href="http://dx.doi.org/10.1016/j.metabol.2013.11.014" target="_blank" >http://dx.doi.org/10.1016/j.metabol.2013.11.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.metabol.2013.11.014" target="_blank" >10.1016/j.metabol.2013.11.014</a>
Alternative languages
Result language
angličtina
Original language name
Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue
Original language description
Objective. In rodents, brown (BAT) and white (WAT) adipose tissues are targets and expression sites for fibroblast growth factor-21 (FGF21). In contrast, human WAT expresses negligible levels of FGF21. We examined FGF21 expression in human BAT samples, including the induced BAT found in adult patients with pheochromocytoma, and interscapular and visceral BAT from newborns. Methods. The expression of FGF21 and uncoupling protein-1 (UCP1, a brown adipocyte marker), was determined by quantitative real-time-PCR and immunoblotting. The transcript levels of marker genes for developmentally-programmed BAT (zinc-finger-protein of the cerebellum-1, ZIC1) and inducible-BAT (cluster of differentiation-137, CD137) were also determined. Results. FGF21 and UCP1 aresignificantly expressed in visceral adipose tissue from pheochromocytoma patients, but not in visceral fat from healthy individuals. In neonates, FGF21 and UCP1 are both expressed in visceral and interscapular fat, and their expression le
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/7E12073" target="_blank" >7E12073: DIABAT - Recruitment and activation of brown adipocytes as preventive and curative therapy for type 2 diabetes</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Metabolism: Clinical and Experimental
ISSN
0026-0495
e-ISSN
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Volume of the periodical
63
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
312-317
UT code for WoS article
000331989100002
EID of the result in the Scopus database
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