Gene Profile of Adipose Tissue of Patients with Pheochromocytoma/Paraganglioma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082497" target="_blank" >RIV/00023001:_____/22:00082497 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10443797 RIV/00064165:_____/22:10443797
Result on the web
<a href="https://www.mdpi.com/2227-9059/10/3/586/htm" target="_blank" >https://www.mdpi.com/2227-9059/10/3/586/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines10030586" target="_blank" >10.3390/biomedicines10030586</a>
Alternative languages
Result language
angličtina
Original language name
Gene Profile of Adipose Tissue of Patients with Pheochromocytoma/Paraganglioma
Original language description
Background: Brown adipose tissue (BAT) is a therapeutic target to combat obesity and related disorders. Pheochromocytoma and functional paraganglioma (PPGL) are associated with activated BAT due to catecholamine excess. Our aim was to evaluate BAT activity by gene profile and assess its relation to clinical characteristics and overproduced catecholamine. Methods: mRNA expression of 15 genes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was measured via RT-PCR in 25 patients with PPGL and 14 controls undergoing cholecystectomy. Results: We found in VAT of PPGL higher expression of UCP1 (p < 0.001), CEBPB, PPARGCIA (both p < 0.001), PRDM16 (p = 0.069) and DIO2 (p = 0.005). UCP1 expression correlated only with norepinephrine levels and its metabolite. UCP1 expression, among others, correlated negatively with BMI, age and positively with HDLc levels. Dominance of BAT or BeAT markers was not assessed in PPGL. In SAT of PPGL, we found higher expression of ADRB3, CIDEA (both p < 0.05), and PPARGCIA (p = 0.001), but not UCP1. Conclusion: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels. However, no direct relationship with increased basal energy metabolism measured by calorimetry was found.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/NV19-01-00083" target="_blank" >NV19-01-00083: IDENTIFICATION OF CRITICAL PROTEINS AND MOLECULAR PATHWAYS INVOLVED IN PHEOCHROMOCYTOMA AND PARAGANGLIOMA DEVELOPMENT AND PROGRESSION</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines
ISSN
2227-9059
e-ISSN
2227-9059
Volume of the periodical
10
Issue of the periodical within the volume
3
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
"Art. no. 586"
UT code for WoS article
000776068400001
EID of the result in the Scopus database
2-s2.0-85125932688