A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00439460" target="_blank" >RIV/67985823:_____/14:00439460 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00702-014-1234-y" target="_blank" >http://dx.doi.org/10.1007/s00702-014-1234-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-014-1234-y" target="_blank" >10.1007/s00702-014-1234-y</a>

Result language

angličtina

Original language name

A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats

Original language description

Endo- as well as exogenous adenosine exhibits anticonvulsant action. Participation of individual types of adenosine receptors was studied in present experiments in immature rats. Cortical epileptic afterdischarges were used as a model in rat pups 12, 18and 25 days old. CCPA, an agonist of A1 adenosine receptors, decreased markedly duration of afterdischarges whereas DPCPX, an antagonist of A1 receptors, exhibited strong proconvulsant action. Action of either drug was best expressed in 12-day-old rats and it decreased with age. Drugs influencing A2A adenosine receptors (agonist CGS21680 and antagonist ZM241385) did not exhibit systematic effects in our model. Motor phenomena accompanying cortical stimulation or epileptic afterdischarge were never influenced by any of the four drugs studied. A1 adenosine receptors are important in the model of cortical seizures, especially in the youngest group studied

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/LH11015" target="_blank" >LH11015: Study of immediate changes after epileptic seizures elicited at different stages of postnatal development</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

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Volume of the periodical

121

Issue of the periodical within the volume

11

Country of publishing house

AT - AUSTRIA

Number of pages

8

Pages from-to

1329-1336

UT code for WoS article

000344353700002

EID of the result in the Scopus database

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