Allosteric regulation of the P2X4 receptor channel pore dilation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00443448" target="_blank" >RIV/67985823:_____/15:00443448 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00424-014-1546-7" target="_blank" >http://dx.doi.org/10.1007/s00424-014-1546-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00424-014-1546-7" target="_blank" >10.1007/s00424-014-1546-7</a>

Result language

angličtina

Original language name

Allosteric regulation of the P2X4 receptor channel pore dilation

Original language description

Ivermectin, allosteric modulator of ATP-gated PX4 receptor-channels, induces conformational changes of the entire protein that alter potencies and efficacies for orthosteric ligands and transition of ion channel from open to dilated state. The kinetic (Markov state) model indicates that the ivermectin-dependent transition is coupled to receptor sensitization, which rescues the receptor from desensitization and subsequent internalization

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pflugers Archiv - European Journal of Physiology

ISSN

0031-6768

e-ISSN

—

Volume of the periodical

467

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

14

Pages from-to

713-726

UT code for WoS article

000351516300009

EID of the result in the Scopus database

2-s2.0-84901868582