A Hydrophobic Filter Confers the Cation Selectivity of Zygosaccharomyces rouxii Plasma-Membrane Na (+)/H (+) Antiporter
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00444083" target="_blank" >RIV/67985823:_____/15:00444083 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jmb.2015.02.012" target="_blank" >http://dx.doi.org/10.1016/j.jmb.2015.02.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jmb.2015.02.012" target="_blank" >10.1016/j.jmb.2015.02.012</a>
Alternative languages
Result language
angličtina
Original language name
A Hydrophobic Filter Confers the Cation Selectivity of Zygosaccharomyces rouxii Plasma-Membrane Na (+)/H (+) Antiporter
Original language description
Na+/H+ antiporters may recognize all alkali metal cations as substrates, but transport them selectively. Plasma-membrane Zygosaccharomyces rouxii Sod2-22 antiporter exports Na+ and Li+, but not K+. A 3D model of the ZrSod2-22 transmembrane domain was generated and suggested a close proximity of Thr141, Ala179 and Val375 from transmembrane segments 4, 5 and 11, respectively, forming a hydrophobic hole in the putative cation pathway?s core. Obtained experimental results confirmed that the three residues found through modelling play a central role in the determination of cation selectivity and transport activity in Z. rouxii Na+/H+ antiporter, and that the cation selectivity can be modulated by repositioning a single local methyl group
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Biology
ISSN
0022-2836
e-ISSN
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Volume of the periodical
427
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
1681-1697
UT code for WoS article
000352665400003
EID of the result in the Scopus database
2-s2.0-84929940003