Translational regulation shapes the molecular landscape of complex disease phenotypes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00444838" target="_blank" >RIV/67985823:_____/15:00444838 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/ncomms8200" target="_blank" >http://dx.doi.org/10.1038/ncomms8200</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ncomms8200" target="_blank" >10.1038/ncomms8200</a>

Result language
angličtina
Original language name
Translational regulation shapes the molecular landscape of complex disease phenotypes
Original language description
We perform genome-wide RNA sequencing and ribosome profiling in heart and liver tissues to investigate strain-specific translational regulation in the spontaneously hypertensive rat (SHR). We observed hundreds of strain-specific differences in translation, almost doubling the number of differentially expressed genes. The integration of genetic, transcriptional and translational data sets revealed distinct signatures in 30 UTR variation, RNA-binding protein motifs and miRNA expression associated with translational regulation of gene expression. Capturing interindividual differences in the translated genome will lead to new insights into the genes and regulatory pathways underlying disease phenotypes
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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