A Difference in Fatty Acid Composition of Isocaloric High-Fat Diets Alters Metabolic Flexibility in Male C57BL/6JOlaHsd Mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00446423" target="_blank" >RIV/67985823:_____/15:00446423 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0128515" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0128515</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0128515" target="_blank" >10.1371/journal.pone.0128515</a>
Alternative languages
Result language
angličtina
Original language name
A Difference in Fatty Acid Composition of Isocaloric High-Fat Diets Alters Metabolic Flexibility in Male C57BL/6JOlaHsd Mice
Original language description
The aim of this study was to determine the effect of high-fat diets with different fatty acid compositions, but similar n6/n3 ratio (with either predominantly PUFAs (HFpu diet) or predominantly SFAs (HFs diet)), on metabolic flexibility. We found that the HFs diet, compared to the HFpu diet, increased mean adipocyte size, liver damage, and ectopic lipid storage in liver and muscle; although, we did not find differences in body weight, total adiposity, adipose tissue health, serum adipokines, whole bodyenergy balance, or circadian rhythm between HFs and HFpu mice. HFs mice were, furthermore, less flexible in their response to both fasting- re-feeding and OxR, while glucose tolerance was indistinguishable. To conclude, the HFs versus the HFpu diet increased ectopic fat storage, liver damage, and mean adipocyte size and reduced metabolic flexibility in male mice. This study underscores the physiological relevance of indirect calorimetry-based challenge tests
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/7E10059" target="_blank" >7E10059: Biomarkets of Robustness of Metabolic - Hoemostasis for nutrigenomics - derived Health claims made on food</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
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UT code for WoS article
000356835800016
EID of the result in the Scopus database
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