Lithium - therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00459564" target="_blank" >RIV/67985823:_____/16:00459564 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Lithium - therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms

Original language description

Mood disorders are relatively common serious human diseases for which there is often no ideal pharmacotherapy. Basic characteristic of these diseases is affective disorder shifting the mood of the patient to depression (together with anxiety or not) or towards to euphoria. Available drugs are usually divided into two groups – mood stabilizers, which are used primarily to treat bipolar disorder, and antidepressants for the treatment of unipolar depression. Lithium is still recommended as the first choice for dealing with bipolar disorder. Despite abundant clinical use of mood stabilizing drugs, important questions regarding their mechanism of action remain open. In this paper we present the brief review of rather diversified hypotheses and ideas about mechanisms of genesis of mood disorders and lithium interferences with these pathological states. New data derived from the high-resolution crystallographic studies of allosteric, Na+-binding sites present in G protein coupled receptors are given together with data indicating the similarity between lithium and magnesium cations. In this context, similarities and dissimilarities between the useful “poison with narrow therapeutic window (Li+) and the bivalent cation acting like cofactor of more than 300 enzymatic reactions (Mg2+) are pointed out together with results indicating enhanced activity of trimeric G proteins in bipolar disorder.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Neurobiologiae Experimentalis

ISSN

0065-1400

e-ISSN

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Volume of the periodical

76

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

19

Pages from-to

1-19

UT code for WoS article

000375636700001

EID of the result in the Scopus database

2-s2.0-84964206606