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Protein nanocoatings on synthetic polymeric nanofibrous membranes designed as carriers for skin cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00474274" target="_blank" >RIV/67985823:_____/17:00474274 - isvavai.cz</a>

  • Alternative codes found

    RIV/61389013:_____/17:00474274 RIV/67985891:_____/17:00474274 RIV/00216208:11130/17:10360964 RIV/00216208:11510/17:10360964

  • Result on the web

    <a href="http://dx.doi.org/10.2147/IJN.S121299" target="_blank" >http://dx.doi.org/10.2147/IJN.S121299</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2147/IJN.S121299" target="_blank" >10.2147/IJN.S121299</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Protein nanocoatings on synthetic polymeric nanofibrous membranes designed as carriers for skin cells

  • Original language description

    Protein-coated resorbable synthetic polymeric nanofibrous membranes are promising for the fabrication of advanced skin substitutes. We fabricated electrospun polylactic acid and poly(lactide-co-glycolic acid) nanofibrous membranes and coated them with fibrin or collagen I. Fibronectin was attached to a fibrin or collagen nanocoating, in order further to enhance the cell adhesion and spreading. Fibrin regularly formed a coating around individual nanofibers in the membranes, and also formed a thin noncontinuous nanofibrous mesh on top of the membranes. Collagen also coated most of the fibers of the membrane and randomly created a soft gel on the membrane surface. Fibronectin predominantly adsorbed onto a thin fibrin mesh or a collagen gel, and formed a thin nanofibrous structure. Fibrin nanocoating greatly improved the attachment, spreading, and proliferation of human dermal fibroblasts, whereas collagen nanocoating had a positive influence on the behavior of human HaCaT keratinocytes. In addition, fibrin stimulated the fibroblasts to synthesize fibronectin and to deposit it as an extracellular matrix. Fibrin coating also showed a tendency to improve the ultimate tensile strength of the nanofibrous membranes. Fibronectin attached to fibrin or to a collagen coating further enhanced the adhesion, spreading, and proliferation of both cell types.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30402 - Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

Result continuities

  • Project

    <a href="/en/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Preparation, modification and characterization of materials by radiation</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Nanomedicine

  • ISSN

    1178-2013

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    Feb

  • Country of publishing house

    NZ - NEW ZEALAND

  • Number of pages

    18

  • Pages from-to

    1143-1160

  • UT code for WoS article

    000393596400001

  • EID of the result in the Scopus database

    2-s2.0-85012286996