/GD-Tracker/ A software for blood-brain barrier permeability assessmentn

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F17%3A00482636" target="_blank" >RIV/67985823:_____/17:00482636 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

/GD-Tracker/ A software for blood-brain barrier permeability assessmentn

Original language description

Epilepsy is chronic neurological disease characterized by occurrence of spontaneous recurrent seizures affecting approximately 1% of people. One of the most common causes of epilepsy in adults is a stroke. The precise mechanism of development of vascular epilepsy is not known, and thus no reliable biomarker of postischemic epileptogenesis currently exists. Blood-brain barrier (BBB) impairment is phenomenon observed in several pathologies including stroke after which epilepsy often develops. Blood components such as albumin or thrombin have been experimentally shown to possess the capacity to increase excitability which results in seizures and epileptogenesis. We hypothesize that severity of the BBB breakdown during first weeks after the stroke can be used as a biomarker of postischemic epileptogenesis. This paper describes free MATLAB based software /Gd-Tracker/ and methodology developed for assessment of BBB permeability from magnetic resonance (MR) scans based on statistical voxel to voxel comparison of sequences with and without Gd-DTPA contrast. This software allows to evaluate extent and magnitude of impaired BBB region and thus serve as a tool for visualization and quantification of BBB breakdown.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Lékař a technika. Biomedicinské inženýrství a informatika

ISSN

0301-5491

e-ISSN

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Volume of the periodical

47

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

43-48

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85027324258