Does Extension of Acute BBB Impairment After Stroke Predict Development of VascularEpilepsy?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F18%3A00325745" target="_blank" >RIV/68407700:21230/18:00325745 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Does Extension of Acute BBB Impairment After Stroke Predict Development of VascularEpilepsy?
Original language description
Purpose:Approximately 5–9% of patients after cerebralstroke develop epilepsy. A precise mechanism of postis-chemic epileptogenesis is not known, however there areseveral currently studied candidates e.g. blood-brain barrier(BBB) defect after ischemia. A reliable biomarker ofpostischemic epilepsy development is needed for properadjustment of postischemic treatment. Aim of this study isto parametrise ischemic lesion and severity of BBB impair-ment in patients after stroke with focus on identification ofparameters candidating as epilepsy biomarker.Method:Five from 150 patients after cerebral ischemiadeveloped epilepsy. 50 patients without and 5 patients withdeveloped epilepsy were randomly selected for furtheranalysis. MRI was measured to all patients 7–12 days afterstroke. MR images were analysed by in-house tailoredalgorithms. Fot detection and parametrization of ischemicregions were used FLAIR (penumbra) and DWI (core)sequences. For detection of BBB impairment after ischemiawere used T1 sequences with and without gadolinium con-trast agent, where gadolinium extravasation was measured.Results:Spatial parameters as volume, overlaps of regionsand location of ischemic lesion, and parameters describingseverity and size of BBB impairment were calculated.Patients which developed epilepsy were compared withthose who did not. Three parameters were significantly dif-ferent between epileptic and nonepileptic patients. Patientsdeveloping epilepsy have larger ischemic regions(p = 0.05) with larger BBB disruption (p = 0.001) andbigger part of BBB impairment was localized outsideischemic regions (p = 0.05) than patients without devel-oped epilepsy...
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů