Differences of Saliva Composition in Relation to Tooth Decay and Gender

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00505673" target="_blank" >RIV/67985823:_____/18:00505673 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/18:10403631 RIV/00216208:11310/18:10403631 RIV/00064165:_____/18:10403631

Result on the web

<a href="https://fb.cuni.cz/file/5885/fb2018a0024.pdf" target="_blank" >https://fb.cuni.cz/file/5885/fb2018a0024.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Differences of Saliva Composition in Relation to Tooth Decay and Gender

Original language description

Most people worldwide suffer from dental caries. Only a small part of the population is caries-resistant and the reason for this resistance in unknown. Only a few studies compared the saliva protein composition of persons with carious teeth and persons with no caries. Our study is the first to relate proteomic analysis of the caries aetiology with gender. In this study, we compared the differences in the abundances of proteins in the saliva between caries-resistant and caries-susceptible females and males by nano-liquid chromatography-tandem mass spectrometry (Label-Free Quantitative Proteomics). Our results demonstrate that the observed differences in the protein levels might have an influence on anti-caries resistance. A total of 19 potential markers of tooth caries were found, for example proteins S100A8 and annexin A1 with higher expression in the caries-susceptible group in comparison with the caries-free group and mucin-5B, lactoferrin, lysozyme C with higher expression in the caries-free group in comparison with the caries-susceptible group. The presented study is the first complex proteomic and gender project where the saliva protein content of caries-free and caries-susceptible persons were compared by label-free MS. The newly detected potential protein markers of dental caries can be a good basis for further research and for possible future therapeutic use.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10406 - Analytical chemistry

Project

<a href="/en/project/NV17-31564A" target="_blank" >NV17-31564A: Improvement of non-invasive fibrosis treatment of congenital pes equinovarus.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

5-6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

195-203

UT code for WoS article

000470083200006

EID of the result in the Scopus database

2-s2.0-85064208000