Trk1, the sole potassium-specific transporter in Candida glabrata, contributes to the proper functioning of various cell processes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00507573" target="_blank" >RIV/67985823:_____/19:00507573 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11274-019-2698-6" target="_blank" >https://link.springer.com/article/10.1007%2Fs11274-019-2698-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11274-019-2698-6" target="_blank" >10.1007/s11274-019-2698-6</a>

Result language
angličtina
Original language name
Trk1, the sole potassium-specific transporter in Candida glabrata, contributes to the proper functioning of various cell processes
Original language description
Candida glabrata is a haploid yeast that is considered to be an emergent pathogen since it is the second most prevalent cause of candidiasis. Contrary to most yeasts, this species carries only one plasma membrane potassium transporter named CgTrk1. We show in this work that the activity of this transporter is regulated at the posttranslational level, and thus Trk1 contributes to potassium uptake under very different external cation concentrations. In addition to its function in potassium uptake, we report a diversity of physiological effects related to this transporter. CgTRK1 contributes to proper cell size, intracellular pH and membrane-potential homeostasis when expressed in Saccharomyces cerevisiae. Moreover, lithium influx experiments performed both in C. glabrata and S. cerevisiae indicate that the salt tolerance phenotype linked to CgTrk1 can be related to a high capacity to discriminate between potassium and lithium (or sodium) during the transport process. In summary, we show that CgTRK1 exerts a diversity of pleiotropic physiological roles and we propose that the corresponding protein may be an attractive pharmacological target for the development of new antifungal drugs.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology

Project
<a href="/en/project/GA16-03398S" target="_blank" >GA16-03398S: Transporters of the pathogenic Candida yeast species as a target for the development of new antifungal drugs.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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