Identification of the building blocks of ventricular septation in monitor lizards (Varanidae)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00507854" target="_blank" >RIV/67985823:_____/19:00507854 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10398842
Result on the web
<a href="https://dev.biologists.org/content/146/14/dev177121" target="_blank" >https://dev.biologists.org/content/146/14/dev177121</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/dev.177121" target="_blank" >10.1242/dev.177121</a>

Result language
angličtina
Original language name
Identification of the building blocks of ventricular septation in monitor lizards (Varanidae)
Original language description
Among lizards, only monitor lizards (Varanidae) have a functionally divided cardiac ventricle. The division results from the combined function of three partial septa, which may be homologous to the ventricular septum of mammals and archosaurs. We show in developing monitors that two septa, the 'muscular ridge' and 'bulbuslamelle', express the evolutionarily conserved transcription factors Tbx5, Irx1 and Irx2, orthologues of which mark the mammalian ventricular septum. Compaction of embryonic trabeculae contributes to the formation of these septa. The septa are positioned, however, to the right of the atrioventricular junction and they do not participate in the separation of incoming atrial blood streams. That separation is accomplished by the 'vertical septum', which expresses Tbx3 and Tbx5 and orchestrates the formation of the electrical conduction axis embedded in the ventricular septum. These expression patterns are more pronounced in monitors than in other lizards, and are associated with a deep electrical activation near the vertical septum, in contrast to the primitive base-to-apex activation of other lizards. We conclude that evolutionarily conserved transcriptional programmes may underlie the formation of the ventricular septa of monitors.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30106 - Anatomy and morphology (plant science to be 1.6)

Project
<a href="/en/project/GA16-02972S" target="_blank" >GA16-02972S: Elucidating cardiac conduction system formation with phylogenetic approaches</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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