Mystery of rhythmic signal emergence within the suprachiasmatic nuclei
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00523831" target="_blank" >RIV/67985823:_____/20:00523831 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1111/ejn.14141" target="_blank" >https://doi.org/10.1111/ejn.14141</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ejn.14141" target="_blank" >10.1111/ejn.14141</a>
Alternative languages
Result language
angličtina
Original language name
Mystery of rhythmic signal emergence within the suprachiasmatic nuclei
Original language description
The circadian system provides organisms with a temporal organization that optimizes their adaptation to environmental fluctuations on a 24-hr basis. In mammals, the circadian clock in the suprachiasmatic nuclei (SCN) develops during the perinatal period. The rhythmicity first appears at the level of individual SCN neurons during the fetal stage, and this step is often misinterpreted as the time of complete SCN clock development. However, the process is only finalized when the SCN begin to play a role of the central clock in the body, that is, when they are able to generate robust rhythmicity at the cell population level, entrain the rhythmic signal with external light-dark cycles and convey this signal to the rest of the body. The development is gradual and correlates with morphological maturation of the SCN structural complexity, which is based on intercellular network formation. The aim of this review is to summarize events related to the first emergence of circadian oscillations in the fetal SCN clock. Although a large amount of data on ontogenesis of the circadian system have been accumulated, how exactly the immature SCN converts into a functional central clock has still remained rather elusive. In this review, the hypothesis of how the SCN attains its rhythmicity at the tissue level is discussed in context with the recent advances in the field. For an extensive summary of the complete ontogenetic development of the circadian system, the readers are referred to other previously published reviews.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/GA16-03932S" target="_blank" >GA16-03932S: Mechanisms of maternal entrainment of the fetal circadian clocks in mammals</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Neuroscience
ISSN
0953-816X
e-ISSN
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Volume of the periodical
51
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
300-309
UT code for WoS article
000510146300018
EID of the result in the Scopus database
2-s2.0-85053869791