The high-resolution proteomic analysis of protein composition of rat spleen lymphocytes stimulated by Concanavalin A, a comparison with morphine-treated cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00523837" target="_blank" >RIV/67985823:_____/20:00523837 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/20:00523837 RIV/00216208:11310/20:10413206

Result on the web

<a href="https://doi.org/10.1016/j.jneuroim.2020.577191" target="_blank" >https://doi.org/10.1016/j.jneuroim.2020.577191</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jneuroim.2020.577191" target="_blank" >10.1016/j.jneuroim.2020.577191</a>

Result language

angličtina

Original language name

The high-resolution proteomic analysis of protein composition of rat spleen lymphocytes stimulated by Concanavalin A, a comparison with morphine-treated cells

Original language description

Morphine- and Concanavalin A-induced changes of protein composition of rat spleen lymphocytes were determined by high-resolution proteomic analysis, gel-free, label-free quantification, MaxLFQ. Stimulation by Con A resulted in a major reorganization of spleen cell protein composition evidenced by increased expression level of 94 proteins, 101 proteins were down-regulated (> 2-fold). Interestingly, among proteins that were up-regulated to the largest extent were the prototypical brain proteins as a neuron specific enolase, synapsin-1, brain acid-soluble protein-1 and myelin basic protein. Morphine-induced change was limited to no more than 5 up-regulated and 18 down-regulated proteins (> 2-fold).

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neuroimmunology

ISSN

0165-5728

e-ISSN

—

Volume of the periodical

341

Issue of the periodical within the volume

Apr 15

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

14

Pages from-to

577191

UT code for WoS article

000521114100009

EID of the result in the Scopus database

2-s2.0-85079849005