Nanosecond Pulsed Electric Field Lab-on-Chip Integrated in Super-Resolution Microscope for Cytoskeleton Imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00524260" target="_blank" >RIV/67985823:_____/20:00524260 - isvavai.cz</a>

Alternative codes found

RIV/67985882:_____/20:00524260 RIV/68378050:_____/20:00524260

Result on the web

<a href="https://doi.org/10.1002/admt.201900669" target="_blank" >https://doi.org/10.1002/admt.201900669</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/admt.201900669" target="_blank" >10.1002/admt.201900669</a>

Result language

angličtina

Original language name

Nanosecond Pulsed Electric Field Lab-on-Chip Integrated in Super-Resolution Microscope for Cytoskeleton Imaging

Original language description

Nanosecond pulsed electric field offers novel opportunities in bionanotechnology and biomedicine enabling ultrafast physical control of membrane, and protein-based processes for the development of novel bionanomaterials and biomedical theranostic methods. However, the mechanisms of nanosecond pulsed electric field action at the nano- and molecular scale are not fully understood due to lack of appropriate research tools. In order to overcome this challenge, a technological platform for the exploration of these mechanisms in live biological samples is provided here. This paper describes step by step the proposed chip platform, including the design, fabrication, installation, and testing of the chip. The developed chip is capable of delivering hundreds of volts of nanosecond electric pulses compared to conventional chips using few volts. Moreover, the chip is fully integrated into a super-resolution microscope. Later on, the chip function is demonstrated by affecting microtubule architecture in living cells. Therefore, the chip-based technological advancement enables the assessment of pulsed electric field effects on bionanostructures and observing their effects in real-time. The results contribute to the chip-based high-frequency bioelectronics technology for modulating the function of biological matter at the nanoscale level

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advanced Materials Technologies

ISSN

2365-709X

e-ISSN

—

Volume of the periodical

5

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1900669

UT code for WoS article

000492740600001

EID of the result in the Scopus database

2-s2.0-85074616711