Interaction of GABA(A) and GABA(B) antagonists after status epilepticus in immature rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00524266" target="_blank" >RIV/67985823:_____/20:00524266 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.yebeh.2019.106683" target="_blank" >https://doi.org/10.1016/j.yebeh.2019.106683</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.yebeh.2019.106683" target="_blank" >10.1016/j.yebeh.2019.106683</a>

Result language

angličtina

Original language name

Interaction of GABA(A) and GABA(B) antagonists after status epilepticus in immature rats

Original language description

Among neurotransmitter systems affected by status epilepticus (SE) in adult rats are both GABAeigic systems. To analyze possible changes of GABA(A) and GABA(B) systems in developing rats lithium-pilocarpine SE was induced at postnatal day 12 (P12). Seizures were elicited by a GABA(A) antagonist pentylenetetrazol (PTZ) 3, 6, 9, and 13 days after SE (i.e., in P15, P18, P21, and P25 rats), and their possible potentiation by a GABA(B) receptor antagonist CGP46381 was studied. Pilocalpine was replaced by saline in control animals (lithium-paraldehyde [LiPAR]).Pentylenetetrazol in a dose of 50 mg/kg s.c. elicited generalized seizures in nearly all 15-day-old naive rats and in 40% of 18-day-old ones but not in older animals. After SE, PTZ no longer elicited seizures in these two younger groups, i.e., sensitivity of GABA(A) system was diminished. The GABA(B) antagonist exhibited proconvulsant effect in P15 and P18 SE as well as LiPAR rats returning the incidence of PTZ-induced seizures to values of control animals. A decrease in the incidence of minimal clonic seizures was seen in P21 LiPAR animals, these seizures in the oldest group were not affected. Change of the effect from proconvulsant to anliconvulsant (or at least to no action) took place before postnatal day 21.Both SE and LiPAR animals exhibited similar changes but their intensity differed, effects in LiPAR controls were usually more expressed than in SE rats.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epilepsy and Behavior

ISSN

1525-5050

e-ISSN

—

Volume of the periodical

102

Issue of the periodical within the volume

Jan

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

106683

UT code for WoS article

000506868100045

EID of the result in the Scopus database

2-s2.0-85075217360