Does status epilepticus induced at early postnatal period change excitability after cortical epileptic afterdischarges?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00464952" target="_blank" >RIV/67985823:_____/16:00464952 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/epi.13438" target="_blank" >http://dx.doi.org/10.1111/epi.13438</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/epi.13438" target="_blank" >10.1111/epi.13438</a>
Alternative languages
Result language
angličtina
Original language name
Does status epilepticus induced at early postnatal period change excitability after cortical epileptic afterdischarges?
Original language description
Possible changes of cortical excitability after status epilepticus (SE) elicited in 12-day-old rats were studied by means of paired cortical afterdischarges (ADs). Consequences of lithium-pilocarpine status were studied in animals with implanted electrodes 3, 6, 9, 13, and 26 days after SE. Paired low-frequency stimulation with a 1-min interval was repeated after 10 min, and duration of ADs was measured. Control rats received saline instead of pilocarpine; other treatments were the same as in SE group. Postictal refractoriness (i.e., the testing response significantly shorter than the conditioning one) appeared at the age of 18 days in lithium-paraldehyde controls, whereas SE animals exhibited this phenomenon since postnatal day 21. The only significant difference between SE and lithium-paraldehyde controls was found in the second conditioning AD in the oldest group studied–it was longer in 38-day-old SE animals. Our results demonstrated moderate signs of higher excitability of SE rats in comparison with control ones long before appearance of spontaneous seizures.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Epilepsia
ISSN
0013-9580
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
"E183"-"E186"
UT code for WoS article
000380750300007
EID of the result in the Scopus database
2-s2.0-84985006935