Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00488661" target="_blank" >RIV/67985823:_____/18:00488661 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.pharep.2017.08.012" target="_blank" >http://dx.doi.org/10.1016/j.pharep.2017.08.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pharep.2017.08.012" target="_blank" >10.1016/j.pharep.2017.08.012</a>

Result language

angličtina

Original language name

Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats?

Original language description

Ifenprodil as a specific antagonist of NMDA receptors containing a dominant NR2Bsubunit exhibits age-dependent anticonvulsant action. Possible changes of this action due to status epilepticus (SE) elicited at early stage of development were studied using cortical epileptic afterdischarges (ADs) as a model. Lithium-pilocarpine SE was induced at postnatal day 12 and effects of ifenprodil were studied 3, 6, 9, and 13 days after SE in rat pups with implanted epiduralelectrodes. Controls (LiPAR) received saline instead of pilocarpine. ADs were elicited by low frequency stimulation of sensorimotor cortex. Intensity of stimulation current increased in 18 steps from 0.2 to 15 mA. Ifenprodil (20 mg/kg) was administered intraperitoneally (ip) after the stimulation with 3.5-mA current. Threshold for four different phenomena as well as duration of ADs were evaluated. The threshold for the transition into the limbic type of ADs was higher in 15-day-old SE rats than in LiPAR controls. Opposite difference was found in 18-day-old animals, older rats did not exhibit any difference. Isolated significant changes in total duration of ADs were found after high stimulation intensities. These changes appeared in 18-day-old rats where ADs were shorter in SE than in control LiPAR rats. Changes in ifenprodil action were found only in the first week after SE but not in the second week. Interpretation of the results is complicated by failure of significant differences between SE and LiPAR rats probably due to a high dose of paraldehyde.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacological Reports

ISSN

1734-1140

e-ISSN

—

Volume of the periodical

70

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

7

Pages from-to

126-132

UT code for WoS article

000428169000020

EID of the result in the Scopus database

2-s2.0-85040651851