Can Maternal Autoantibodies Play an Etiological Role in ASD Development?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00531281" target="_blank" >RIV/67985823:_____/20:00531281 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10411848 RIV/00216208:11130/20:10411848 RIV/00064203:_____/20:10411848

Result on the web

<a href="https://www.dovepress.com/can-maternal-autoantibodies-play-an-etiological-role-in-asd-developmen-peer-reviewed-article-NDT" target="_blank" >https://www.dovepress.com/can-maternal-autoantibodies-play-an-etiological-role-in-asd-developmen-peer-reviewed-article-NDT</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S239504" target="_blank" >10.2147/NDT.S239504</a>

Result language

angličtina

Original language name

Can Maternal Autoantibodies Play an Etiological Role in ASD Development?

Original language description

Autism spectrum disorder (ASD) is a heterogeneous condition with multiple etiologies and risk factors - both genetic and environmental. Recent data demonstrate that the immune system plays an important role in prenatal brain development. Deregulation of the immune system during embryonic development can lead to neurodevelopmental changes resulting in ASD. One of the potential etiologic factors in the development of ASD has been identified as the presence of maternal autoantibodies targeting fetal brain proteins. The type of ASD associated with the presence of maternal autoantibodies has been referred to as maternal antibodies related to ASD (MAR ASD). The link between maternal autoantibodies and ASD has been demonstrated in both clinical studies and animal models, but the exact mechanism of their action in the pathogenesis of ASD has not been clarified yet. Several protein targets of ASD-related maternal autoantibodies have been identified. Here, we discuss the role of microtubule-associated proteins of the collapsin response mediator protein (CRMP) family in neurodevelopment and ASD. CRMPs have been shown to integrate multiple signaling cascades regulating neuron growth, guidance or migration. Their targeting by maternal autoantibodies could change CRMP levels or distribution in the developing nervous system, leading to defects in axon growth/guidance, cortical migration, or dendritic projection, which could play an etiological role in ASD development. In addition, we discuss the future possibilities of MAR ASD treatment.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/NV18-04-00085" target="_blank" >NV18-04-00085: The role of maternal autoantibodies in pathogenesis of autism spectrum disorders</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychiatric Disease and Treatment

ISSN

1178-2021

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

Jun

Country of publishing house

NZ - NEW ZEALAND

Number of pages

8

Pages from-to

1391-1398

UT code for WoS article

000537737600001

EID of the result in the Scopus database

2-s2.0-85085978936