Understanding FAHFAs: From structure to metabolic regulation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00532332" target="_blank" >RIV/67985823:_____/20:00532332 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.plipres.2020.101053" target="_blank" >https://doi.org/10.1016/j.plipres.2020.101053</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.plipres.2020.101053" target="_blank" >10.1016/j.plipres.2020.101053</a>
Alternative languages
Result language
angličtina
Original language name
Understanding FAHFAs: From structure to metabolic regulation
Original language description
The discovery of branched fatty acid esters of hydroxy fatty acids (FAHFAs) in humans draw attention of many researches to their biological effects. Although FAHFAs were originally discovered in insects and plants, their introduction into the mammalian realm opened new horizons in bioactive lipid research. Hundreds of isomers from different families have been identified so far and their role in (patho) physiological processes is currently being explored.The family of palmitic acid esters of hydroxy stearic acids (PAHSAs), especially 5-PAHSA and 9-PAHSA regioisomers, stands out in the crowd of other FAHFAs for their anti-inflammatory and anti-diabetic effects. Beneficial effects of PAHSAs have been linked to metabolic disorders such as type 1 and type 2 diabetes, colitis, and chronic inflammation. Besides PAHSAs, a growing family of polyunsaturated FAHFAs exerts mainly immunomodulatory effects and biological roles of many other FAHFAs remain currently unknown. Therefore, FAHFAs represent unique lipid messengers capable of affecting many immunometabolic processes.The objective of this review is to summarize the knowledge concerning the diversity of FAHFAs, nomenclature, and their analysis and detection. Special attention is paid to the total syntheses of FAHFAs, optimal strategies, and to the formation of the stereocenter required for optically active molecules. Biosynthetic pathways of saturated and polyunsaturated FAHFAs in mammals and plants are reviewed together with their metabolism and degradation. Moreover, an overview of biological effects of branched FAHFAs is provided and many unanswered questions regarding FAHFAs are discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA20-00317S" target="_blank" >GA20-00317S: New metabolic pathways involved in synthesis of anti-diabetic lipids</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Progress in Lipid Research
ISSN
0163-7827
e-ISSN
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Volume of the periodical
79
Issue of the periodical within the volume
Jul
Country of publishing house
GB - UNITED KINGDOM
Number of pages
22
Pages from-to
101053
UT code for WoS article
000565148200007
EID of the result in the Scopus database
2-s2.0-85088951686