Neonatal Hypoxic-Ischemic Brain Injury Leads to Sex-Specific Deficits in Rearing and Climbing in Adult Mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00538473" target="_blank" >RIV/67985823:_____/20:00538473 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/20:10422717
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/2020/69_S499.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/2020/69_S499.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934604" target="_blank" >10.33549/physiolres.934604</a>
Alternative languages
Result language
angličtina
Original language name
Neonatal Hypoxic-Ischemic Brain Injury Leads to Sex-Specific Deficits in Rearing and Climbing in Adult Mice
Original language description
The study examined the morphological and long-term behavioral impacts of neonatal hypoxic-ischemic brain injury in a mouse model. We investigated the modification of different behavioral domains, such as spontaneous climbing, which represents fine motor skills. We also focused on sex-dependent differences during hypoxic-ischemic encephalopathy. The Rice-Vannucci model of hypoxia-ischemia was used, adjusted and adapted to 7-day-old C57BL/6NTac mice. The effects of induced hypoxia and ischemia were also studied separately. At postnatal day 60, mice underwent behavioral testing using the LABORAS apparatus. The perfusion for histological evaluation was performed one day after the behavioral analyses. In groups with separately induced hypoxia or ischemia, the observed alterations in behavior were not accompanied by morphological changes in the cortex or hippocampal formation. Female mice naturally climbed significantly more and hypoxic females reared less than hypoxic males (p<0.05). Male mice postnatally exposed to hypoxiaischemia exhibited significantly lower vertical activity and higher horizontal activity (p<0.05). Mild hypoxic damage may not be morphologically detectable but may induce substantial behavioral changes in adult mice. There were significant differences between horizontal and vertical activity in reaction to hypoxiaischemia. Our study indicates that the importance of behavioral testing is irreplaceable and may be reflected in neonatal medicine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
—
Volume of the periodical
69
Issue of the periodical within the volume
Suppl.3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
14
Pages from-to
"S499"-"S512"
UT code for WoS article
000610191500014
EID of the result in the Scopus database
2-s2.0-85100326691