Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00508598" target="_blank" >RIV/67985823:_____/19:00508598 - isvavai.cz</a>
Result on the web
<a href="https://www.nrcresearchpress.com/doi/10.1139/cjpp-2019-0060#.XljPJKhKiUk" target="_blank" >https://www.nrcresearchpress.com/doi/10.1139/cjpp-2019-0060#.XljPJKhKiUk</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1139/cjpp-2019-0060" target="_blank" >10.1139/cjpp-2019-0060</a>

Result language
angličtina
Original language name
Developmental and sex differences in cardiac tolerance to ischemia-reperfusion injury: the role of mitochondria
Original language description
Age and sex play an essential role in the cardiac tolerance to ischemia-reperfusion injury: cardiac resistance significantly decreases during postnatal maturation and the female heart is more tolerant than the male myocardium. It is widely accepted that mitochondrial dysfunction, and particularly mitochondrial permeability transition pore (MPTP) opening, plays a major role in determining the extent of cardiac ischemia-reperfusion injury. We have observed that the MPTP sensitivity to the calcium load differs in mitochondria isolated from neonatal and adult myocardium, as well as from adult male and female hearts. Neonatal and female mitochondria are more resistant both in the extent and in the rate of mitochondrial swelling induced by high calcium concentration. Our data further suggest that age-and sex-dependent specificity of the MPTP is not the result of different amounts of ATP synthase and cyclophilin D: neonatal and adult hearts, similarly as the male and female hearts, contain comparable amounts of MPTP and its regulatory protein cyclophilin D. We can speculate that the lower sensitivity of MPTP to the calcium-induced swelling may be related to the higher ischemic tolerance of both neonatal and female myocardium.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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