Sex Differences in Cardiac Tolerance to Oxygen Deprivation – 40 Years of Cardiovascular Research

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00602158" target="_blank" >RIV/67985823:_____/24:00602158 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/24:10487891 RIV/00216208:11130/24:10487891

Result on the web

<a href="https://www.biomed.cas.cz/physiolres/pdf/2024/73_S511.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2024/73_S511.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.935429" target="_blank" >10.33549/physiolres.935429</a>

Result language

angličtina

Original language name

Sex Differences in Cardiac Tolerance to Oxygen Deprivation – 40 Years of Cardiovascular Research

Original language description

Experimental and clinical studies have clearly demonstrated significant sex differences in myocardial structure and function, both under physiological and pathological conditions. The best example are significant sex differences in the cardiac tolerance to ischemia/reperfusion injury: pre-menopausal adult female hearts are more resistant as compared to the male myocardium. The importance of these findings is supported by the fact that the number of studies dealing with this issue increased significantly in recent years. Detailed molecular and cellular mechanisms responsible for sex differences are yet to be elucidated, however, it has been stressed that the differences cannot be explained only by the effect of estrogens. In recent years, a promising new hypothesis has been developed, suggesting that mitochondria may play a significant role in the sex differences in cardiac tolerance to oxygen deprivation. However, one is clear already today: sex differences are so important that they should be taken into consideration in the clinical practice for the selection of the optimal diagnostic and therapeutic strategy in the treatment of ischemic heart disease. The present review attempts to summarize the progress in cardiovascular research on sex-related differences in cardiac tolerance to oxygen deprivation during the last 40 years, i.e. from the first experimental observation. Particular attention was paid to the sex-related differences of the normal heart, sex-dependent tolerance to ischemia-reperfusion injury, the role of hormones and, finally, to the possible role of cardiac mitochondria in the mechanism of sex-dependent differences in cardiac tolerance to ischemia/reperfusion injury.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

1802-9973

Volume of the periodical

73

Issue of the periodical within the volume

Suppl.2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

15

Pages from-to

"S511"-"S525"

UT code for WoS article

001414553400005

EID of the result in the Scopus database

2-s2.0-85210777194