Sex Differences in Cardiac Ischemia/Reperfusion Injury

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F20%3A00537904" target="_blank" >RIV/67985823:_____/20:00537904 - isvavai.cz</a>
Alternative codes found
RIV/00023884:_____/20:00008827
Result on the web
<a href="https://doi.org/10.1007/978-3-030-58677-5_2" target="_blank" >https://doi.org/10.1007/978-3-030-58677-5_2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-030-58677-5_2" target="_blank" >10.1007/978-3-030-58677-5_2</a>

Result language
angličtina
Original language name
Sex Differences in Cardiac Ischemia/Reperfusion Injury
Original language description
I tis now well known that differences in the structure and function of the heart exist between male and female hearts. Several lines of exerimental and clinical investigations have reported that there are sex differences in the tolerance to myocardial ischemia, whereby adult male hearts are more susceptible to ischemia/reperfusion (I/R) injury as compared to pre-menopausal female hearts. Experimental studies have also shown that adult female hearts have increased resistence and male hearts are more susceptible to I/R in animal exposed to perinatal hypoxia. Although there is now a large body of evidence which indicates that estrogen is involved in the sex differences with respect to cardiac tolerance to ischemia, the exact mechanisms involved in the cardiac response to ischemia or hypoxia are not fully understood. Accordingly, this chapter is intended to describe some of the known molecular nad cellular mechanisms that contribute to sex differences in the susceptibility to I/R injury. With such a new basic information and advancements in the understanding of the mechanisms responsible for sex differences in cardiac sensitivity to ischemic injury, it is hoped that some specific therapeutic strategies will be developed for post-menopausal females for better quality of life, and lower mortality.
Czech name
—
Czech description
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Project
<a href="/en/project/GA18-03207S" target="_blank" >GA18-03207S: Cardiac ischemic tolerance of spontaneously hypertensive rats expressing human C-reactive protein.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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