Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00541688" target="_blank" >RIV/67985823:_____/21:00541688 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10427448 RIV/00023001:_____/21:00080663
Result on the web
<a href="https://doi.org/10.1139/cjpp-2020-0310" target="_blank" >https://doi.org/10.1139/cjpp-2020-0310</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1139/cjpp-2020-0310" target="_blank" >10.1139/cjpp-2020-0310</a>
Alternative languages
Result language
angličtina
Original language name
Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults
Original language description
Epidemiological studies have demonstrated a relationship between the adverse influence of perinatal development and increased risk of ischemic heart disease in adults. From negative factors to which the fetus is subjected, the most important is hypoxia. The fetus may experience hypoxic stress under different conditions, including pregnancy at high altitude, pregnancy with anemia, placental insufficiency, and heart, lung, and kidney disease. One of the most common insults during the early stages of postnatal development is hypoxemia due to congenital cyanotic heart defects. Experimental studies have demonstrated a link between early hypoxia and increased risk of ischemia/reperfusion injury (I/R) in adults. Furthermore, it has been observed that late myocardial effects of chronic hypoxia, experienced in early life, may be sex-dependent. Unlike in males, perinatal hypoxia significantly increased cardiac tolerance to acute I/R injury in adult females, expressed as decreased infarct size and lower incidence of ischemic arrhythmias. It was suggested that early hypoxia may result in sex-dependent programming of specific genes in the offspring with the consequence of increased cardiac susceptibility to I/R injury in adult males. These results would have important clinical implications, since cardiac sensitivity to oxygen deprivation in adult patients may be significantly influenced by perinatal hypoxia in a sex-dependent manner.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Canadian Journal of Physiology and Pharmacology
ISSN
0008-4212
e-ISSN
1205-7541
Volume of the periodical
99
Issue of the periodical within the volume
1
Country of publishing house
CA - CANADA
Number of pages
8
Pages from-to
1-8
UT code for WoS article
000613249900001
EID of the result in the Scopus database
2-s2.0-85099853569