Expression of Opioid Receptors in Cells of the Immune System
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00541562" target="_blank" >RIV/67985823:_____/21:00541562 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/21:00541562 RIV/00216208:11310/21:10438941
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/1/315" target="_blank" >https://www.mdpi.com/1422-0067/22/1/315</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22010315" target="_blank" >10.3390/ijms22010315</a>
Alternative languages
Result language
angličtina
Original language name
Expression of Opioid Receptors in Cells of the Immune System
Original language description
The observation of the immunomodulatory effects of opioid drugs opened the discussion about possible mechanisms of action and led researchers to consider the presence of opioid receptors (OR) in cells of the immune system. To date, numerous studies analyzing the expression of OR subtypes in animal and human immune cells have been performed. Some of them confirmed the expression of OR at both the mRNA and protein level, while others did not detect the receptor mRNA either. Although this topic remains controversial, further studies are constantly being published. The most recent articles suggested that the expression level of OR in human peripheral blood lymphocytes could help to evaluate the success of methadone maintenance therapy in former opioid addicts, or could serve as a biomarker for chronic pain diagnosis. However, the applicability of these findings to clinical practice needs to be verified by further investigations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
22
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
315
UT code for WoS article
000606078100001
EID of the result in the Scopus database
2-s2.0-85098880723