Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F21%3A00544568" target="_blank" >RIV/67985823:_____/21:00544568 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/21:43920642
Result on the web
<a href="https://doi.org/10.1016/j.neulet.2021.136098" target="_blank" >https://doi.org/10.1016/j.neulet.2021.136098</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neulet.2021.136098" target="_blank" >10.1016/j.neulet.2021.136098</a>
Alternative languages
Result language
angličtina
Original language name
Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions
Original language description
Schizophrenia is a debilitating mental disorder characterized by positive, negative and cognitive symptoms. Whereas positive symptoms are satisfactorily addressed by current antipsychotic treatment, negative and cognitive symptomatic treatment remains largely ineffective. This review investigates the treatment efficacy regarding cognitive symptoms and evaluates the contribution of different monoamine receptor systems involved in schizophrenia pathophysiology to cognition. In the review, we included preclinical studies assessing the effect of different treatments on cognition in pre-pulse inhibition and two spatial cognitive tests. While pre-pulse inhibition investigates pre-attentive processes operating outside of conscious awareness, the spatial tasks require continuous attention and active engagement in task solving for a successful outcome. The schizophrenia-like phenotype was attained by acute or subchronic administration of non-competitive NMDA receptor antagonist MK-801.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroscience Letters
ISSN
0304-3940
e-ISSN
1872-7972
Volume of the periodical
761
Issue of the periodical within the volume
Sep 14
Country of publishing house
IE - IRELAND
Number of pages
7
Pages from-to
136098
UT code for WoS article
000672856300001
EID of the result in the Scopus database
2-s2.0-85110107795